Aldol condensation in water

Figure 45. Asymmetric Si()2-Sc-IL catalysed aldol condensation in water.

In this respect, the use of water as a solvent for enantioselective reaction has been explored. In 2006 Barbas and co-workers developed an efficient proline-derived chiral catalyst (Scheme 5.5) for aldol condensation in water with high reactivity, diastereoselectivity and enantioselectivity. 

Tanemura, K., Suzuki, T., Nishida, Y. and Horaguchi, T., Aldol condensation in water using polyethylene glycol 400, Chem. Lett., 2005, 34, 576-577. 

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See also in sourсe #XX -- [ , ]

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