Aldol condensation enzyme assisted

Enzyme assisted aldol condensation was the key step of the synthesis of 3-deoxy-D-ara mo-heptulosonic acid 7-phosphate (Scheme 63) [154], In the four steps synthesis of DAHP Whitesides started from A-acetyl -D/L-aspartate P-semialdehyde and dihydroxyacetone phosphate. The required threo stereochemistry was generated by using commercial rabbit muscle aldolase as catalyst. 

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