Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Aldehydes, reduction with Grignard reagents

Most pyrimidine carbonitriles show normal nitrile chemistry reductive reactions to methylamines by metal hydrides, hydrolytic reactions, reduction to aldehydes and formation of ketones with Grignard reagents. However, in highly electron-deficient pyrimidines, competition may arise between addition to an electrophilic substituent and the electrophilic pyrimidine ring. In the 5-cyano derivative (426), specific attack of organometallics is in the 4-position, with formation of the dihydro derivatives (427) instead of a ketone <83ACS(B)6I3>. [Pg.183]

See other pages where Aldehydes, reduction with Grignard reagents is mentioned: [Pg.69]    [Pg.84]    [Pg.732]    [Pg.733]    [Pg.96]    [Pg.115]    [Pg.266]    [Pg.807]    [Pg.84]    [Pg.694]    [Pg.732]    [Pg.733]    [Pg.807]    [Pg.597]    [Pg.279]    [Pg.861]    [Pg.224]    [Pg.84]    [Pg.439]    [Pg.125]    [Pg.1331]    [Pg.732]    [Pg.733]    [Pg.254]    [Pg.188]    [Pg.125]    [Pg.284]    [Pg.165]    [Pg.732]    [Pg.733]    [Pg.572]    [Pg.603]    [Pg.604]    [Pg.113]    [Pg.96]    [Pg.463]    [Pg.1474]   
See also in sourсe #XX -- [ Pg.604 ]



SEARCH



Aldehydes Grignard reagents

Aldehydes reagents

Aldehydes reduction

Aldehydes reductive

Aldehydes with Grignard reagents

Grignard reduction

Reduction reagents

With Grignard Reagents

© 2024 chempedia.info