Aldehyde dehydrogenase gene family

Aldehyde dehydrogenases (ALDH), a large superfamily of enzymes produced by 19 human genes in 11 families and 13 subfamilies. 

Vasiliou V, Nebert DW. Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomic 2005 2 138-143. 

The mannose portion of GDP-mannose is oxidized in an NAD" -dependent reaction to generate GDP-mannuronate. The reaction is catalyzed by GDP-mannose dehydrogenase (GMD), a member of the small family of enzymes that catalyze the four-electron oxidation of their substrates. The reaction thus requires two equivalents of NAD per catalytic cycle, and proceeds through an intermediate that is at the oxidation state of an aldehyde. GMD is encoded by the algD gene in P. aeruginosa, and the subunit contains 435 amino acids. Early studies of GMD were conducted by Chakrabarty and co-workers." ... 

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