Alcoholysis or Phenolysis of Nuclear Halogenopyrazines

2-Chloro-3,5-diphenylpyrazine (118, R = Cl) gave 2-methoxy-3,5-diphenyl-pyrazine (118, R = OMe) (MeONa, MeOH, reflux, 3 h 97%) homologues likewise.1307 [Pg.160]

2-Chloro-3,6-diphenylpyrazine (119, R = Cl) gave 2-ethoxy-3,6-diphenylpyra-zine (119, R = OEt) (EtONa, EtOH, reflux, 4 h 89%)82 or 2-phenoxy-3, 6-diphenylpyrazine (119, R = OPh) [(PhO)3PO, KOH, Me2NCHO, reflux, 1 h 81% substituted-phenoxy analogues were made likewise].192 [Pg.160]

2-Chloro-3,6-dimethylpyrazine gave 2,5-dimethyl-3-(2,2,2-trifluoroethoxy)pyrazine [NaOCH2CF3 (prepared in situ), (Me2N)3PO, 150°C, 12 h 54%].787 [Pg.161]

3-Chloro-2-pyrazinamine (121, R = Cl) gave 3-benzyloxy-2-pyrazinamine (121, R = OCH2Ph) (PhCH2ONa, PhCH2OH, warmed , 72 h 58% sometimes accompanied by a separable byproduct, 2-benzylamino-3-benzy-loxypyrazine (122), in small amount.1567, cf-616 [Pg.161]

5-Dibromo-2-pyrazinamine (123, R = Br) gave 3-benzyloxy-5-bromo-2-pyrazinamine (123, R = OCH2Ph) (PHCH2ONa, PhCH2OH, reflux, 4 h 51%) 661 also analogues likewise.661 Also other examples.1012 1198 [Pg.161]

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