Alcohol To hydride

Few attempts to determine the thermodynamic characteristics of proton transfer from alcohols to hydrides can be found in the literature. [32a, 47] However, the NMR technique used in those studies has obvious limitations in that it does not allow the determination of the equilibrium concentrations for each intermediate in Eq. 11 and the calculation of their formation constants. These limitations originate from the averaging of the hydride signal in the H NMR spectrum due to a fast interconversion between 1 and 2. Similar technical difficulties also occasionally arise in the IR investigations, resulting for instance from the overlap of the v o bands of the initial hydride 1 and the H-bonded adduct 2. 

---