Fluorine-containing secondary alcohol

Another fluorine-containing compound used for this purpose is a-cyano-a-fluoro-p-tolylacetic acid (CFTA). The structure of this compound is shown in Figure 80, and it is used for secondary alcohols ( H NMR) and amines ( F NMR see Section 3.4.5.1). The procedure requires the preparation of the esters from the two enantiomers of CFTA and measurement of the value (5(5) - 5(i )) for the substituents (Li/ L2) of the alcohol. The assignment is based on the fact that, in the ester derived from (S)-CFTA, substituent Li is shielded by the fluorophenyl group whereas in the (i -CFTA ester, the shielded substituent is L2 (see Figure 83). 

Class II Other liquids composed of molecules containing both active hydrogen atoms and donor atoms (oxygen, nitrogen, and fluorine)—e.g., alcohols, acids, phenols, primary and secondary amines, oximes, nitro compounds with alpha-hydrogen atoms, nitriles with alpha hydrogen atoms, ammonia, hydrazine, HF, HCN (plus nitromethane, acetonitrile even though these form 3-dimensional networks they have weaker bonds than —OH and —NH bonds in class I)... 

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