Albumin atypical

Hepatic adenoma consists of atypical, strand-like hepa-tocytes. It is characterized by normal perfusion and an extensive absence of Kupffer cells as well as irregularity of the bile ducts. Scintigraphically, it is possible to demonstrate that there is no elimination of iminodiacetates from the adenoma and that uptake of the radioactive tracer is prolonged compared with the normal liver parenchyma ( trapping on IDA scans). (38) No colloidal albumin or Tc-colloid is taken up - this allows differentiation of an adenoma from focal nodular hyperplasia. The use of the SPECT technique increases sensitivity. 

Of special interest are discoveries of transient atypical albumins which may be observed only in disease. Scheurlen (S14) and Wuhrmann (W32) have described a patient with diabetes mellitus, who during several years showed the double anomaly only when her diabetes was out of control. On the first occasion when it was found, she had acute cystopyelitis. The additional albumin band disappeared after treatment, but appeared again at renewed decompensation. On later occasions the anomaly appeared during precomatose episodes, after which it disappeared again. More lately, however, the double albumin band has become constantly present in the plasma of this patient (W32). 

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