Aklavinone 11-hydroxylase

Aklavinone, the product of the DauE reaction (Figure 12), is the major precursor commort to all of the anthracycUnes of the daunorubicin-adacinomycin-rhodomycin families, including adacinomycin, aklavin, daunorubicin, doxorubicin, pyrromycin, carminomycin, rhodomycin, and the cinerubirts (124). S. penceriMs dnrF, which encodes an apparent flavoprotein with a deduced subunit M, of 52,289, has been characterized by several groups to encode aklavinone 11-hydroxylase (223-226). This gene has been used... 

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