Akita, Hiroyuki

Kentaro Kogure, Hidetaka Akita, Hiroyuki Kamiya, and Hideyoshi Harashima... 

In the 1980s, Hiroyuki Akita and Takeshi Oishi published an enantioselective synthesis of oudemansin A, where a jS-keto-ester is reduced stereoselectively to the jS-hydroxy-ester with Candida albicans. After chromatographic purification from small amounts of diastereomers, the ester is then homologised in a classical reduction and cyanide substitution sequence. The remainder of the synthesis for establishing the acrylate system follows the previously described methodology. [53-55]... 

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