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Transformation ajmaline into raumacline

Scheme 13. Transformation of ajmaline (17) into raumacline (144). Reagents i. NaBH, MeOH, citrate bosphate buffer 6.0) ii. riboflavin, hv. Scheme 13. Transformation of ajmaline (17) into raumacline (144). Reagents i. NaBH, MeOH, citrate bosphate buffer 6.0) ii. riboflavin, hv.
An efficient transformation of maline (17) into raumacline (144), which is a biotransformation product of ajmaline in cell cultures of Rauvolfia serpentina, was developed by Endress and StSckigt (168). Ajmaline (17) was reduced with NaBH4 in citrate/phosphate buffered solution (pH 6.0) to 4,21-secoajmaline (145), which, by riboflavin-sensitized photo-oxidation, afforded raumacline (144) in 86% total yield (Scheme 13). [Pg.43]


See other pages where Transformation ajmaline into raumacline is mentioned: [Pg.43]    [Pg.46]   
See also in sourсe #XX -- [ Pg.43 ]

See also in sourсe #XX -- [ Pg.43 ]




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