Agrochemicals chirality, role

A molecule is chiral if it has a non-superimposable mirror image (Figure 2.1). The most eommon cause of chirality in molecules is the presence of asym-metrie earbon atom(s). The majority of pharmaceuticals and natural products are in single-enantiomer form. Asymmetric synthesis plays a key role in the preparation of these compounds of interest. Stereoselective synthesis of chiral compounds, as defined by lUPAC, is a chemical reaction in which one or more new elements of chirality are formed in a substrate molecule, producing the stereoisomeric products in unequal amounts. Asymmetric synthesis is particularly important in the fields of pharmaceuticals and agrochemicals, because the different enantiomers or diastereomers of a molecule often have different biological activities. 

The asymmetric synthesis of chiral fluoroorganic compounds plays an important role in the development of medicines, agrochemicals and materials due to the influence of fluorine s unique properties.In this context, Backvall s... 

The asymmetric synthesis of chiral fluoroorganic compounds plays an important role in the development of medicines, agrochemicals, and materials due to the influence of fluorine s unique properties. In this context, Bogar and Backvall investigated the DKR of various fluorinated aryl alcohols, in 2007. As shown in Scheme 8.17, a series of chiral fluorinated acetates were produced in remarkably high yields and enantioselectivities by using a combination of CALB with Backvall s catalyst in the presence of isopropenyl acetate as the acyl donor at room temperature. 

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