Agonists, Antagonists, and Reuptake Blockers

More recently, based on the structures of more rigid dopamine antagonists, a pharmacophore model has been developed which appears to be consistent with the available 

Conformational Search Medium-sized Molecules Drug Design Opioid Agonists and Antagonists Pharmacophore and Drug Discovery Systematic and Random Search Methods for Finding Conformers of Molecules. 

Freeman and J. D. McDermed, in Chemical Regulation of Biological Mechanisms , eds. A. M. Creighton and S. Turner, Royal Society, London, 1982, pp. 154-166. 

Nichols, in Dopamine Receptors , eds. J. W. Kebabian and C. Kaiser, American Chemical Society, Washington, 1X2, 1983, pp. 201-218. 

Malrieu and B. Pullman, Theor. Chim. Acta (Berlin), 1964, 2, 293-301. 

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Conformational Search Medium-sized Molecules Dopamine Agonists, Antagonists, and Reuptake Blockers Drug... 

Listing of antidepressants grouped by principal mechanism of action in the synapse. Abbreviations MAOI—irreversible = irreversible monoamine oxidase inhibitor MAOI—reversible = reversible monoamine oxidase inhibitor NDRl = norepinephrine/ dopamine reuptake inhibitor NRI = norepinephrine reuptake inhibitor NSRl = norepinephrine/serotonin reuptake inhibitor NSSA = norepinephrine/specific serotonin agonist SRI = serotonin reuptake inhibitor SRl/serotonin-2 blocker = serotonin reuptake inhibitor and serotonin-2 receptor antagonist. 

Opioids, benzodiazepines, barbiturates, corticosteroids, dopamine agonists (e.g., amantadine, bromocriptine, levodopa, pergolide, pramipexole, ropinirole), H2-receptor antagonists, anticholinergics (e.g., diphenhydramine, trihexylphenidyl), P-adrenergic blockers, clonidine, methyldopa, carbamazepine, phenytoin, baclofen, cyclobenzaprine, lithium, antidepressants (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors), and interleukin-2... 

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