Agmatine aldehyde

Satriano J, Schwartz D, Ishizuka S, Lortie MJ, Thomson SC, Gabbai F, Kelly CJ, Blantz RC Suppression of inducible nitric oxide generation by agmatine aldehyde Beneficial effects in sepsis. J Cell Physiol 188 313-320,2001... 

In fermented foods, the non-volatile or biogenic amines (histamine, putrescine, cadaverine, spermine, spermidine, agmatine, tyramine tryptamine) and phenylethylamine (a volatile amine) are formed mainly by the microbial decarboxylation of the corresponding amino acids (Ten Brink et al. 1990). Volatile amines are believed to be formed by the reductive amination or transamination of the corresponding aldehyde or ketone. 

The development of thrombin inhibitors that lack the functionalized TSA highlights a major new approach to type I peptidomimetics. In 1995, a Lilly group found that D-Phe-Pro-Agmatine analogs showed increased selectivity for thrombin over other fibrinolytic enzymes despite a 100-fold loss in potency caused by the removal of the aldehyde group (160). These studies paved the way for Merck s development of picomolar thrombin inhibitors (161,162), which use a similar motif Removal of an a-ketoamide transition state mimic from L-370,518 (89) (Fig. 15.39,... 

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