Aging skin hands

The effectiveness of the stratum corneum in blocking the passage of chemicals varies from one part of the human body to another. It is particularly difficult for chemicals to cross the palms of the hands and soles of the feet, but they get by the scrotum fairly easily. Abdominal skin is of intermediate effectiveness in preventing absorption. Age and sex also influence rates of dermal absorption, and some species... 

A potentially fatal lung toxicity occurs in 10 to 20% of patients receiving bleomycin. Patients particularly at risk are those who are over 70 years of age and have had radiation therapy to the chest. Rarely, bleomycin also may cause allergic pneumonitis. Bleomycin skin toxicity is manifested by hyperpigmentation, erythematosus rashes, and thickening of the skin over the dorsum of the hands and at dermal pressure points, such as the elbows. Many patients develop a low-grade transient fever within 24 hours of receiving bleomycin. Less common adverse effects include mucositis, alopecia, headache, nausea, and arteritis of the distal extremities. 

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