Aggregation, deuterium oxide

Effect of Deuterium Oxide on Protein Aggregation in Deuterio and Protio Phycocyanin and Other Proteins... 

Ericsson, C.A. Soderman, O. Garamus, V.M. Bergstrom, U.S. Effects of temperature, salt and deuterium oxide on the self-aggregation of alkylglycosides in dilute solution. 2. n-tetradecyl-/ -D-maltoside. Langmuir 2005, 21, 1507-1515. 

The mixtures showed broadened absorption spectra compared to those of individual spectra indicating the formation of aggregate due to the electrostatic attractions between the cationic and anionic porphyrins. The size of the aggregate were expected larger than 5 x lO m since the filtrated solution from a membrane filter showed neither absorption nor. photoactivity. Use of deuterium oxide or heavy water as solvent had no effect on the emission intensities suggesting involvement of singlet oxygen is unlikely in this process. 

Somewhat higher K factors are obtainable where moderators such as deuterium oxide or beryllium are used. Thus with beryllium it is possible to secure a K factor 60 as high as 1.10 with optimum geometry and absolute purity. Moreover with deuterium oxide K factors of about 1.27 may be obtained. When such moderators are used the problem of aggregation may be somewhat less important although it Is an essential factor if maxi-65 mum K factors and minimum size reactors are to be obtained. 

Willumsen, N., Vaagenes, H., Holmsen, H. Beige, R.K. 19%) Biochim. Biophys. Acta-, 1369, 193-203 On the effect of 2-deuterium- and 2-methyl-eicosapentaenoic acid derivatives on triglycerides, peroxisomal P-oxidation and platelet aggregation in rats. 

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