Soluble noncovalent aggregates, large

Glucagon-Like Peptide-1 Analog Large Soluble Noncovalent Aggregates... 

Nonpolar molecules tend to have low solubilities in water, and large nonpolar solutes tend to form aggregates in aqueous solution. In the past these tendencies were sometimes explained by invoking a special hydrophobic bond between nonpolar groups. However, bond is a misnomer here, and it is better to refer to an effect, because there is no exchange of bonding electrons involved in either of the tendencies noted above. Instead, the hydrophobic effect is a combination of several of the fundamental noncovalent interactions, and it involves details of the organization of water molecules around nonpolar solute molecules. 

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