Afterspike hyperpolarization

Bradykinin is a mediator that may be considered as both an activator (as discussed earlier) and a modulator. One mechanism by which bradykinin modulates C-fiber excitability is blockade of calcium-dependent potassium currents responsible for an afterspike hyperpolarization (Weim-eich et al. 1995). This effect is mediated by bradykinin B2 receptors, although the latter effect on the afterspike hyperpolarization appears to be secondary to prostacyclin production by the neuron. 

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