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Afferent nerve terminal, action

In behavioral tests, the actions of peripherally-administered ATP are pro-nociceptive. These nociceptive responses have been suggested to be due to direct activation of peripheral nerve terminals (Hies and Norenberg, 1993). ATP produces depolarization when applied to the cell bodies of primary afferent neurons located within the dorsal root ganglia (DRG) (Jahr and Jessell, 1983). The depolarizing effect of ATP results from the activation of a non-selective cation channel (Bean, 1990) and is blocked by P2 purinoreceptor antagonists (Tsuda et al., 1999), indicating that excitation is mediated via ionotropic P2X purinoreceptors. [Pg.490]

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See also in sourсe #XX -- [ Pg.282 , Pg.290 , Pg.674 ]



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