Adverse drug reactions biliary

The Swedish adverse drug reactions register, SWEDIS, received 149 case reports of 157 adverse reactions associated with disulfiram from 1971 to 1999, of which 63 cited disorders of the liver and biliary tract (26). Of these 63 reports, seven were classified as serious. In three cases of severe liver damage with a fatal outcome, disulfiram was suspected to have caused the reaction. If signs of liver damage appear, it is recommended that disulfiram be withdrawn and liver function tests performed. 

Dose-independent, drug-induced liver dysfunction (cholestatic jaundice) is not an unusual adverse reaction. Caused by a number of different, commonly used drugs, cholestasis is a hypersensitivity reaction that primarily affects the biliary canaliculi, causing an intrahepatic obstructive jaundice. An alteration in... 

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