Advantages and shortcomings of SPME

SPME is also an excellent tool for extracting compounds amenable to GC, which provides an alternative to well-established sample preparation methods for polar compounds based on on-line SPE-HPLC. 

One other potential problem arises from carry-over of the fibre, which may occur with some analytes (e.g. organochlorine pesticides) and is difficult to suppress — even at high desorption temperatures. If the problem exists, the best solution is to perform blank GC runs with a fibre between successive samplings. 

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