Advances in amination of nitrogen heterocycles

Nitrogen heterocycles see also N-Heterocyclic compounds) advances in amination of, 49, 117 aromatic six-membered. regioselective substitution in, 44, 199 conformational equilibria in saturated six-membered rings, 36, I covalent hydration in, 20, 117 photochemistry of, 30, 239 reactions of acetylenecarboxylic esters with, 23, 263... 

Many natural products, drugs, or plant protection agents are amino-nitrogen heterocycles. Thus, methods for their efficient synthesis are of considerable practical and technical interest. This chapter will discuss primarily the advances made in the amination of nitrogen heterocycles since the comprehensive review by Shepherd and Fedrick on Reactivity of Azine, Benzoazine, and Azinoazine Derivatives with Simple Nucleophiles was published in this series in 1%5 (65AHC145). 

Six articles cover general aspects of heterocyclic chemistry 1,3-dipolar cycloreversions, syntheses with arylnitrenes and a-metallated isocyanides, and photo-oxygenation of nitrogen heterocycles,while others deal with more specialized subjects, i.e. preparation and use of halogeno-lactones, aspects of the chemistry of furan, 1-hydroxy-indoles, ring-opening of azoles by the action of amines, " the use of 2-chlorobenzoxazolium (1) and other heterocyclic onium salts for dehydration and condensation reactions," the synthesis of monosub-stituted tetrathiafulvalenes (2), cycloadditions of azoles containing three heteroatoms,sydnone imines (3), the conversion of acyl-benzofuroxans into nitro-indazoles (cf. p. 199), and advances in the chemistry of pyrrolizidine " and indolizine." ... 

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