Advances in 3D Search Methodology

A 3D database cannot be screened without a binding model hypothesis to define the search (although many searches are based solely on potentially interesting molecular features, with little thought given to a specific binding mode). To this end, a host of techniques have been devised to create, define, and 

The aims of this chapter are to detail many of these advances and give examples of the success of 3D searching and related CADD tools in drug design problems. 

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