Adult CNS Function

CX3CL1 is a unique chemokine distinguished structurally by the presence of a CX3C motif as well as transmembrane spanning and mucin-like domains it shows atypical constitutive expression in a number of nonhematopoietic 

A variety of other chemokine receptors have been detected on neurons in vitro and in situ (see Table II). Treatment of cultured neurons with chemokine ligands for these receptors generally induces increases in intracellular calcium. Activation of these receptors appears to induce survival benefits and modulation of neurotransmission along the same lines as CXCR4. 

Neuronal Chemokine Receptor Expression in the Adult Central Nervous System 

Cortical, spinal cord CXCR2 human Horuk et at., 1997 Xia, 1997 

For example, CXCR2 activation in cerebellar slices protects granule cells from apoptosis through a mechanism that requires AMPA receptor 

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