Adriamycin intracellular levels

The release of iron from intracellular ferritin stores is thought to involve the reduction of Fe to Fe " (Funk et al., 1985) and one would expect this reduction to be fecilitated by the low oxygen tension, increased levels of reducing species and the low pH shown by nuclear magnetic resonance (NM to be as low as 6.9 after only 6 h of cold storage (Fuller et al., 1988). Exogenous redox-active quinones such as adriamycin have been shown to catalyse lipid peroxidation in the presence of ferritin under hypoxic conditions (Vile and Winterbourne, 1988), and lipid peroxidation is stimulated in micro-somes in the presence of purified ferritin and flavin... 

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