Adrenergic receptors buspirone

For panic disorder, tricychc antidepressants and MAO inhibitors, as well as high-potency benzodiazepines (notably alprazolam, clonazepam, and lorazepam) (see Chapter 16), are effective in blocking the autonomic expression of panic itself, thereby facilitating a comprehensive rehabilitation program. Imipramine and phenelzine are well-studied antidepressants for panic disorder. SSRIs also may be effective, but /3 adrenergic receptor antagonists, buspirone, and low-potency benzodiazepines usually are not, and bupropion can worsen anxiety. 

WB 4101 and pH]-5-methylurapidil can only be used to label fi-HTj receptors if Oi-adrenergic receptors are blocked in order to use [ H]-NAN-190 not only aj-adrenergic but also dopamine-Dj receptors need to be blocked. Dopamine-D2 receptors also have to be blocked to allow the use of pH]-spiroxatrine or PH]-buspirone. pH]-Rauwolscine not only has a modest potency (about 1/10 of DPAT), but it is also necessary to block Oj-adrenergic receptors. 

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