ADME Filters GPSVS vs. Ro

Having established that GPSVS is compliant with the BCS system [5] regarding oral bioavailability, we further discuss its performance in comparison to RoS compliance [6] for the WOMBAT-PK dataset. RoS compliance for drugs with respect to %Oral, Cl and is shown in Table 11.4. Without examining VD j and Cl, 0 and 1 RoS violations capture 80% and 1S% of the total number of drugs, respectively. 

yet poor oral availability) and 4 are false negatives (Q2, Ro5 2, but medi-um/good oral availability). Thus, the combination of GPSVS and Ro5 has a 0.7% false negative rate, and a 5% false positive rate. We conclude that this combination provides a very effective tool for ADME filtering. 

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