Adenovirus vectors

Nasimuzzaman M, Kuroda M, Dohno S, Yamamoto T, Iwatsuki K, Matsuzaki S, Mohammad R, Kumita W, Mizuguchi H, Hayakawa T, Nakamura H, Taguchi T, Wakiguchi H, Imai S (2005) Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNAl. Mol Ther 11 578-590... 

A final problem for bioinformatics and bioanalytical scientists is the characterization of engineered microorganisms. Whole-cell analysis by mass spectrometry has been used to confirm the introduction of therapeutic genes into adenovirus vectors,100 to confirm the expression of recombinant proteins in bacteria,101,102 and also in vaccinology.103 In the broader case, identification of... 

Massie, B., Dionne, J., Lamarche, N. et al. (1995) Improved adenovirus vector provides herpes simplex virus ribonucleotide reductase R1 and R2 subunits very efficiently. Bio/Technology (Nature Publishing Company), 13 (6), 602-608. 

Krasnykh, V., Belousova, N., Korokhov, N., Mikheeva, G., and Curiel, D. T. (2001). Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin./ Virol. 75, 4176-4183. 

Mercier, G. T., Campbell, J. A., Chappell, J. D., Stehle, T., Dermody, T. S., and Barry, M. A. (2004). A chimeric adenovirus vector encoding reovirus attachment protein sigmal targets cells expressing junctional adhesion molecule 1. Proc. Natl. Acad. Sci. USA 101, 6188-6193. 

A new gene is injected into an adenovirus vector, which is used to introduce the modified DNA into a human cell. If the treatment is successful, the new gene will make a functional protein. 

Araki K, Ohashi Y, Sasabe T, Kinoshita S, Hayashi K, Yang XZ, Hosaka Y, Aizawa S, Handa H. Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector. Invest Ophthalmol Vis Sci 34 2665-2671 (1993). 

Marshall E. Gene therapy death prompts review of adenovirus vector. Science 1999 286(5448) 2244 2245. 

Harris, J.D., Graham, I.R., Schepelmann, S., et al. (2002) Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation (E1-, E3-, polymerase-) adenovirus vector expressing human apoE. Hum. Mol. Genet., 11, 43-58. 

The mutation of the p53 tumor suppressor gene has been well recognized to be associated in most head and neck malignancies. ONYX-015 is an adenovirus vector com-... 

Yen N, Ioannides CG, Xu K, et al. Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumor injection of an adenovirus vector expressing wild-type p53 (Ad-p53). Cancer Gene Ther 2000 7 530-536. 

Fig. 9. Graph shows the logarithm of relative tumor volume as a function of days after treatment. Growth of tumors treated with adenovirus vector (dark square) or with radiation therapy (dark triangle) is diminished relative to that in the control group (light circle). Tumors receiving combined treatment (dark diamond) decreased in size over time. Error bars = SD.

Okada,T.,W.J Ramsey, J Munir, O.Wildner, and R.M. Blaese, Efficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. Nucleic Acids Res, 1998.26(8) 1947-50. 

Schiedner, G. (1998). Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat. Genet., 18, 180-183. 

Gilardi, P., Courtney, M., Pavirani, A., Perricaudet, M. (1990). Expression of human alpha 1-antitrypsin using a recombinant adenovirus vector. FEBS Lett., 267(1), 60-62. 

Croyle, M.A. (2002). PEGylation of El-deleted Adenovirus vectors allows significant gene expression on readministration to liver. Hum. Gene Ther., 13, 1887-1900. 

Zhang L, Sanker U, Lampe DJ, et al. The Himarl mariner transposase cloned in a recombinant adenovirus vector is functional in mammalian cells. Nucleic Acids Res 1998 26(16) 3687—3693. 

Amalfitano A, Parks RJ. 2002. Separating fact from fiction Assessing the potential of modified adenovirus vectors for use in human gene therapy. Curr Gene Ther. 2 111-133. 

Einfeld DA, Roelvink PW. 2002. Advances towards targetable adenovirus targetable adenovirus vectors for gene therapy. Curr Opin Mol Ther. 4 444-451. 

Steinwaerder, D.S. and Lieber, A. (2000) Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo. Gene Then, 7, 556-567. 

Borrelli, M.J., Schoenherr, D.M., Wong, A., Bemock, L.J. and Corry, P.M. (2001) Heat-activated transgene expression from adenovirus vectors infected into human prostate cancer cells. Cancer Res., 61, 1113-1121. 

Nakagawa, S., Massie, B. and Hawley, R.G. (2001) Tetracycline-regulatable adenovirus vectors pharmacologic properties and clinical potential. EurJ. Pharm. Sci., 13, 53-60. 

Gibson, S.A., Pellenz, C., Hutchison, R.E., Davey, F.R. and Shillitoe, E.J. (2000) Induction of apoptosis in oral cancer cells by an anti-bcl-2 ribozyme delivered by an adenovirus vector. Clin. Cancer Res., 6, 213-222. 

Toloza, E.M., Hunt, K., Swisher, S., McBride, W., Lau, R., Pang, S., Rhoades, K., Drake, T., Belldegrun, A., Glaspy, J. and Economou, J.S. (1996) In vivo cancer gene therapy with a recombinant interleukin-2 adenovirus vector. 

Marshall, D.J., Palasis, M., Lepore, J.J. and Leiden, J.M. (2000) Biocompatibility of cardiovascular gene delivery catheters with adenovirus vectors An important determinant of the efficiency of cardiovascular gene transfer. Mol. Then, 1,423 129. 

Rosengart, T.K., Lee, L.Y., Patel, S.R., Sanbum, T.A., Parikh, M., Bergman, G.W. et al. (1999a) Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation, 100, 468 174. 

Adenovirus vectors are known to be taken into cells by endocytosis and to be released from endosomes by a well regulated process, assumed to be highly efficient [84]. It is therefore somewhat surprising that PCI is able to increase the number of adenoviral transduced cells by up to 30-fold. Nevertheless, PCI with adenoviral vectors has been tested in several different cell lines, and in all cases improved transduction has been observed [85]. The adenovirus activated by means of PCI seems to follow the same cellular pathways as for conventional adenovims infection, i.e., the fraction of transduced cells followed a linear relationship with the Coxsackie and Adenoviral Receptor (CAR) level of the cells and is integrin dependent. Furthermore, PCI increase the number of nuclearly located viral DNA molecules as measured by real-time PCR and fluorescence in situ hybridization (FISH) [86]. The results so far indicate that the main cause of the PCI effect on transduction with adenovirus is related to enhanced release of the viral particles from the endocytic vesicles into the cytosol. In accordance with what has been found for PCI of plasmids the adenovirus may be delivered after the photochemical treatment (unpublished results). However, adenovirus may be delivered up to 12 h after the photochemical treatment, which is longer than what is effective for PCI of plasmids [43, 87]. 

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