Adenosine 3 -thio-, preparation

In order to increase the chemical stability of ATP derivatives that possess long thioether tethers, the 1-thiotriphosphate analogues (86) have been prepared from 2-thio-adenosine. These compounds were fourfold more stable to pig pancreas type I ATPDase than ATP. They were also more potent than ATP at stimulating intracellular response and were established as new insulin secreta-... 

There has been a further report on the introduction of the [[2-(methylthio)phenyl]thio] methyl (MPTM) protecting group into the 2 -position of adenosine, guanosine and cytidine building blocks for oligonucleotide synthesis (See Vol. 25, p. 270).300 Some thioacetals and dithioorthoesters at 0-5 of FdU, such as 213 have been prepared and subjected to y-radiolysis.30i... 

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