Adenosine thiamin diphosphate AThDP

Figure 5.4 Structural formulae of thiamin phosphate esters. At present, five natural thiamin phosphate derivatives have been described thiamin monophosphate (ThMP) thiamin diphopshate (ThDP) thiamin triphosphate (ThTP) adenosine thiamin diphosphate (AThDP) and adenosine thiamin triphosphate (AThTP). Catalytic intermediates, such as for instance a-hydroxyethyl thiamine diphosphate formed by the action of yeast pyruvate decarboxylase (EC 4.1.1.1), are not considered here.

ThTP through its ability to phosphorylate proteins (Nghiem et al. 2000). Thiamin is the only known natural organic molecule that is not a nucleotide but forms mono-, di- and triphospho-derivatives. Recently, even thiamin adenylated derivatives have been described adenosine thiamin diphosphate (AThDP) and adenosine thiamin triphosphate (AThTP) (Bettendorff et al. 2007 Frederich et al. 2009). 

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