Adenosine-homocysteine condensing

In the continuing search for isozyme-specific inhibitors of rat methionine adenosyltransferases, the covalent conjugate (119) of L-ethionine and adenylyl imidodiphosphate has been prepared. 23 in the synthetic route, protected adenosine was converted to its 5 -aldehyde, condensed with vinylmagnesium bromide, and hydroboration, tosylation and condensation with L-homocysteinate served to introduce the L-ethionine moiety, the 5 -hydroxy group then being phosphorylated by Tener s method and converted conventionally to the p, y-imidotriphosphate. 

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