Adenosine, allyl amino

A photophysical study of the interaction of 2-amino-4,6-dimethylpyrimidine in p-CD has been carried out. Calculations have been carried out in an examination of the isomerism of methyl urocanate. Density functional theory techniques have been used to study the dimerization of thymine units in DNA. The effects of both low intensity irradiation (254 nm) or laser photolysis at 266 nm on adenosine have been reported. The photoionization of various purine and pyrimidine derivatives can be brought about by 266 nm nanosecond laser photolysis. Irradiation of alloxan in the presence of alkenes with allylic hydrogens affords adducts of 5-hydroxy-5-alkenyl barbituric acid. When the alkene is... 

Two useful derivatives whose syntheses are not described here are the 2 -<7-allylinosine monomer (13,14), and the 2 -6 -allyl-2-amino-adenosine monomer (13,14). The 2 -0-allylinosine monomer is obtained from compound 12 by desilylation, oximate reaction (requires 24 h reflux in acetonitrile), and dimethoxytritylation followed by phosphitylation. The 2 -0-allyl-2-aminoadenosine monomer is obtained from compound 20 by protection of the exocyclic ammo groups followed by desilylation, dimethoxytritylation, and finally phosphitylation. 

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