Fanconi syndrome adefovir

In 37 patients with hepatitis B virus infection, including 17 with hepatic cirrhosis, who were given adefovir plus lamivu-dine, serum creatinine concentrations rose in 14 cases and serum phosphate concentrations fell in six [9 ]. Those who took combination therapy for 36 months or longer had a significantly increased incidence of raised serum creatinine concentrations. Fanconi syndrome occurred in a 57-year-old woman with cirrhosis after adefovir was added to lamivudine. 

A 58-year-old man developed Fanconi syndrome and acute renal insufficiency after taking adefovir 10 mg/day for more than 1 year there was also generalized osteoporosis... 

Izzedine H, Kheder-Elfekih R, Housset P, Sarkozy C, Brocheriou I, Deray G. Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient. AIDS 2009 23(4) 544-5. 

Wu C, Zhang H, Qian Y, Wang L, Gu X, Dai Z. Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil a case report and literature review suggesting ethnic predisposition. J Clin Pharm Ther 2013 38(4) 321-6. 

Urinary tract Hypophosphatemic osteomalacia due to Fanconi s syndrome occurred in a 40-year-old man there were hyperphospha-turia, hypercalciuria, glycosuria, and massive aminoaciduria [30 ]. In another case, a 66-year-old man who had been taking adefovir for more than 4 years developed osteomalacia with hypophosphatemia [31 ]. 

---