Additional Advice for Design Component of DMTA

Laws are like sausages - it is best not to see them made. 

This remark comparing laws and sausages is well known, and nonchemists might view the synthesis of new molecules in the same vein. However, a lesser known misattribution that may resonate with all members of a lead generation team is that of the fable The Mice In Council (often thought to be one of Aesop s, but not actually within his canon). It is well summarized by its Wikipedia entry  

The feble concerns a group of mice who debate plans to nullify the threat of a marauding cat. One of them proposes placing a bell around its neck, so that they are warned of its approach. The plan is applauded by the others, until one mouse asks who will volunteer to place the bell on the cat. All of them make excuses. The story is used to teach the wisdom of evaluating a plan not only on how desirable the outcome would be, but also on how it can be executed. It provides a moral lesson about the fundamental difference between ideas and their feasibility, and how this affects the value of a given plan. [17] 

The direct question the practical mouse asks is, Who shall bell the cat and this is clearly central to reducing any molecular design to practice. The accessibility of chemical transformations continues to expand, and any siunmary of the state of the art quickly becomes stale. But in addition to marshaling the ever-increasing powers of organic synthesis, flow chemistry, parallel synthesis techniques, and so on, there are additional considerations within the make component of the DMTA cycle in lead generation. 

Key questions to address within Make component of DMTA 

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