Addition of Alcohols to Ynamines and Ynamides Ficini-Claisen Rearrangement

Addition of Alcohols to Ynamines and Ynamides (Ficini-Claisen Rearrangement) 

Although the Ficini-Claisen reaction has shown a considerable scope of applications this method has been somewhat limited by the instability and synthetic inaccessibility of ynamines [18, 19]. Recentiy, ynamides have emerged as alternatives to ynamines in the Ficini-Claisen reaction [20]. Ynamides are more stable and easier to handle than ynamines but also less reactive. Chiral ynamides, e.g., 17, can 

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