Acyloin reaction Silicon modification

This synthesis works well, using the silicon modification 25 of the acyloin reaction, but the final dehydration leads to a mixture of enone 22 with the rearranged enone 26. This problem was not realised until chemists8 began to use this published procedure,9 and is a warning to all chemists involved in synthesis to check the structure of their intermediates carefully by NMR. 

The silicon modification of the acyloin reaction see Chapter 24) is useful for making five-membered rings from 1,5-diesters. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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