Acyllithium intramolecular conversion

The major advances in this field have been brought about by the authors group at Osaka University. As a strategy for attaining highly selective reactions via acyllithium, we employed intramolecular conversion. A number of tactics as shown in Scheme 5-2 and following sections were devised. It should be mentioned that these reactions are no longer acylation via acyllithium but, rather, various type of enolate reactions derived from them. 

Scheme 5-2. Tactics for intramolecular conversion of acyllithium. 1) CO / EtjO, -78 °C MejSiO pSiMej...

Intramolecular Conversion of Acyllithium 139 Table 5-1. Preparation of acylsilanes and their enol sily ethers. 

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