Acylation of Organomanganese Reagents

Functionalized organomanganese reagents prepared from activated manganese can also be acylated. A catalytic amount of copper salts is sometimes required to perform the reaction (Schemes 29to 31) [8,31]. 

Recently, a new efScient substitution reaction of ortho-acylated aryl chlorides by organomanganese reagents has been reported [43]. Yields are generally excellent and the reaction readily takes place under very mild conditions with an excellent chemoselectivity (Scheme 13.60). Indeed, halogenoalkanes (Cl, Br, I), nitriles, esters and ketones are tolerated. 

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