Acylation benzo -fused rings

Azete, trisdimethylamino-isolation, 7, 278 Azetes, 7, 237-284, 278-284 benzo fused, 7, 278 benzodiazepine fused applications, 7, 284 fused ring, 7, 341-362 structure, 7, 360 2,3-naphtho fusion, 7, 278 reactivity, 7, 279 structure, 7, 278 synthesis, 7, 282-283 Azetidine, acylring expansion, 7, 241 synthesis, 7, 246 Azetidine, 3-acyl-irradiation, 7, 239 synthesis, 7, 246 Azetidine, N-acyl-synthesis, 7, 245 Azetidine, alkyl-synthesis, 7, 246 Azetidine, 3-alkylthio-synthesis, 7, 246 Azetidine, 3-amino-synthesis, 7, 246 Azetidine, N-amino-oxidation, 7, 241 synthesis, 7, 246 Azetidine, aryl-synthesis, 7, 246... 

Alkylation and acylation at nitrogen in l-oxa-2,4-diazines, and the benzologs, has been discussed previously in summary, regioselective alkylation is possible at N-4 of 4/7-1-oxa-2,4-diazin-5(677)-ones, and acylation at N-2 of 2/7-benzo-l-oxa-2,4-diazines is slow <1996CHEC-II(6)651>. The N-2-alkylated l-oxa-2,4-diazines 68 and 69 have been produced as potential pesticides <2005W02005116032> the N-2-acylated fused-ring derivative 70 has been claimed as a reverse-turn peptidomimetic with potential anticancer activity <2002W02002096872>. 

The electron-rich thiophene ring system can be elaborated into complex, fused thiophenes by acid-mediated intramolecular annelation reactions. For example, treatment of alcohol 96 with trimethylsilyl triflate promoted a Friedel-Crafts acylation and subsequent dehydration giving benzo[b]thiophene 97, a potential analgesic <00JMC765>. Treatment of ketone 98 with p-toluenesulfonic acid resulted in the formation of fused benzo[b]thiophene 99 <00T8153>. Another variant involved the cyclization of epoxide 100 to fused benzo[f>]thiophene 101 mediated by boron trifluoride-etherate . 

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