2- Acylamino-2-desoxy aldoses

Acetylneuram nic acid. The yield and stereoselectivity of the aldol condensation of 2-acetamido-2-dc.soxy-r>-manno.sc (1) with oxalacetic acid (2) to give N-acetyl-ncuraminic add (3) are improved by adding sodium tetraborate to (he reaction, which is carried out in aqueous solution at pH 10. Thus in the absence of borate ion, yields of (3) ofl 1.5 % have been reported, whereas addition of borate improves the yield to 21.6%. I he borate ion inhibits the alkaline cpimerization of various 2-acylamino-2-desoxy-aldoses. 

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See also in sourсe #XX -- [ ]

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