Acyclic Aminal and Hemiaminal Synthesis

Following a similar strategy, Vellalath et al. realized the direct asymmetric N,0-acetalization of aldehydes by employing a novel chiral bisphosphorylimide 78 as 

SCHEME 2,21 Phosphoric acid-catalyzed asymmetric synthesis of cychc aminals. 

SCHEME 222 Bisphosphorylimide-catalyzed asymmetric N,0-acetalization of aldehydes. 

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