Acute lymphocytic leukemia remission induction

Acute lymphocytic leukemia Induction vincristine plus prednisone. Remission maintenance mercaptopurine, methotrexate, and cyclophosphamide in various combinations Asparaginase, daunorubicin, carmustine, doxorubicin, cytarabine, allopurinol,1 craniospinal radiotherapy... [Pg.1310]

Glucotropic steroids have antianabolic effects on lymphocytes and fibroblasts and are therefore useful in remission induction of chronic and acute lymphocytic leukemia (ALL)... [Pg.135]

O w Minimal bone marrow sup pression and alopecia, hepatotoxic, pancreotoxic, CNS disturbances, inhibits clotting, hyperglycemia. IV or IM. Induction of remission in acute lymphocytic leukemia. Drug may induce anaphylaxis. Available in Erwinia or E. Co//origin (different allergenic potentials)... [Pg.131]

Bestatin (ubenimex) is a potent inhibitor of aminopeptidase N and aminopeptidase B,89 which was isolated from a culture filtrate of Streptomyces olivoreticuli during the search for specific inhibitors of enzymes present on the membrane of eukaryotic cells.90 Inhibitors of aminopeptidase activity are associated with macrophage activation and differentiation, Bestatin has shown significant therapeutic effects in several clinical trials.91 In a multi-institutional study,92 patients with acute non-lymphocytic leukemia (ANLL) were randomized to receive either Bestatin or placebo orally after completion of induction and consolidation therapy, and concomitant with maintenance chemotherapy. Remission duration was prolonged in the Bestatin group, although this difference did... [Pg.162]

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