Acute heat pain latency

Another study found that low doses of ouabain did not modify the acute heat pain latency, but higher doses caused excitation and motor impairment, suggesting that ouabain does not produce a pronounced effect on the pain threshold (Horvath et al., 2003). It is supposed that the controversial results might be due to the fact that ouabain produces its effect on all of the cells, inasmuch as all have Na, K -ATPase, and its net effects on transmitter releases might be dose-dependent. 

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