Acute coronary syndromes defining

Define the role of an atherosclerotic plaque, platelets, and coagulation system in an acute coronary syndrome. 

The term acute coronary syndrome (ACS) encompasses most of the patients defined so far in this chapter who present with unstable ischemic heart disease. Most of these syndromes occur in response to an acute event in the coronary artery when circulation to a region of the heart is obstructed. If the obstruction is high grade and persists, then necrosis usually ensues. Since necrosis takes some time to develop, it is apparent that therapy, including opening the blocked coronary artery in a timely fashion, often can prevent some of the death of myocardial tissue. These syndromes are usually, but not always, associated with chest discomfort. 

The troponin assay has prognostic information that can determine mortality risk in acute coronary syndrome and define which patients may benefit from aggressive medical therapy and early coronary revascularisation. 

Define ST Acute coronary syndrome with angiographic or autoposy evidence of thrombus or occle... 

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