Active pharmaceutical ingredients identification testing

IR spectroscopy is often the method of choice for chemical identification on specifications for release of an active pharmaceutical ingredient and is included in all the major pharmacopoeias. This method is simple, reliable and ensures correct chemical identification when compared with the spectrum of a suitable reference standard. However, the sample preparation required means that carrying out these tests can become time-consuming and there is little opportunity for automation in addition, poor sample preparation can lead to erroneous results. 

Pachaly, P. (ed) Simple Thin-layer Chromatographic Identification of Active Ingredients in Essential Drugs, Gesundheitshilfe Dritte Welt, German Pharma Health Fund e. V, ECV, Aulendorf 1994. Brochure for the identification and purity testing of pharmaceutical agents in the Third World. 

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