Wikstroemia indica activator from

Nunome, S. et al.. In vitro antimalarial activity of biflavonoids from Wikstroemia indica, Planta Med., 70, 76, 2004. 

Kato A, Hashimoto Y, Kidokoro M 1979 (+)-Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. J Nat Prod 42 159-162... 

Daphnoretin (4) is a dicoumarin isolated from Th3mielaceous plants, (Wikstroemia indica. Daphne mezereum and D. cannabind) that directly activates PKC, which in turn elicits the respiratory burst in rat neutrophils. 

Antimalarial screening of the active n-BuOH extract from the root of Wikstroemia indica led to the isolation of two biflavonoids, sikokianin B (136) and sikokianin C (137), with IC50 values of 0.54 pg/mL and 0.56 pg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. [88]... 

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