Activated aryl ethers acetylation

Acetylation of activated aryl ethers with AAN over different zeolites can be efficiently performed under relatively mild conditions. ... 

Another type of (9-glycosides (127), 12-(3 aryl ethers of dihydroartemisinin, was synthesized by a reaction of acetyl dihydroartemisinin or trifluoroacetyl dihydroartemisinin with various substituted phenols in the presence of trifluoroacetic acid. Most of these compounds were proved to have better antimalarial activity against P. berghei in mice than qinghaosu, but less activity than artemether. Unexpectedly,... 

Synthetically valuable methods for the efficient acylation of aryl ethers with anhydrides over different BEA zeolites under batch conditions are also reported. Significant results are summarized in Table 4.9. The reaction can be performed without solvent, and the catalyst can be reused in the acetylation of anisole with unchanged activity for three further cycles after recovery and regeneration by heating in air at 550°C for 3 h. ... 

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