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Action of Hepatic Carcinogens

Can be compiete carcinogens Tumoligemcity is dose responsive No theoreticai threshold Nonmutagenic Threshold, reversible Tumorigenicity is dose responsive May function at tumor promotion stage No direct DNA damage Species, strain, tissue specificity [Pg.423]

TABLE 16.4. Proposed Mechanisms of Action for Selected Hepatic Carcinogens... [Pg.424]

The mechanism of action for liver toxicity and carcinogenicity may involve the formation of reactive products (Bonse and Henschler 1976 Bonse et al. 1975 Fisher et al. 1991 Larson and Bull 1992b). Methods for reducing the destructive damage caused by these intermediates, or for blocking their formation through inhibition of metabolic pathways may prove effective in reducing hepatic toxicity but are not currently available for clinical use. [Pg.191]

See other pages where Action of Hepatic Carcinogens is mentioned: [Pg.423]    [Pg.425]    [Pg.427]    [Pg.429]    [Pg.431]    [Pg.433]    [Pg.434]    [Pg.423]    [Pg.425]    [Pg.427]    [Pg.429]    [Pg.431]    [Pg.433]    [Pg.434]    [Pg.226]    [Pg.242]    [Pg.56]    [Pg.559]    [Pg.2993]    [Pg.562]    [Pg.819]    [Pg.147]    [Pg.58]    [Pg.170]    [Pg.423]    [Pg.433]    [Pg.569]    [Pg.2992]    [Pg.265]    [Pg.151]    [Pg.433]    [Pg.55]    [Pg.282]    [Pg.79]    [Pg.274]    [Pg.91]    [Pg.123]    [Pg.124]    [Pg.91]    [Pg.123]    [Pg.124]    [Pg.334]    [Pg.19]    [Pg.276]    [Pg.18]    [Pg.866]    [Pg.467]    [Pg.440]    [Pg.285]    [Pg.10]   


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Carcinogens hepatic

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