Actinomadura hibisca

Pradimicins A-C, new antifungal antibiotics, have been isolated from Actinomadura hibisca culture broth they contain a benzo[a] naphthacenequinone chromophore with attached 4-amino-4,6-dideoxy-D-galactose, and, with A and C, a /5-D-xylopyranose glycosidically 0-3 linked to the amino-sugar. N,N-Dimethyl-pradimicins have been synthesized by reductive methylation, which improves water solubility and antifungal activity. ... 

Actinomadura hibisca (pradimicin A is (8), R=NHMe). A related aglycone is present in some new antibiotics SF 2446 A1-A3 and B1-B3, generalized in structure (9) in these compounds 2,4-di-O-methyl-... 

---

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

---