ACRL toxin Illb

Whilst the ACRL Toxin I totally synthesized in this way is the main and most toxic component of the toxins produced by the phytopathogenic fungus Alternaria citri (68), other synthetic work has concentrated on a minor, essentially non-toxic component, i. e. ACRL Toxin Illb (63) (69, 70) - a task considerably easier as lack of a stereocenter in the pyranoid ring greatly facilitates the joining of the acyclic and pyranoid fragments. 

Most Lewis acids such as zinc bromid in methanol, dichtoroethylalane in di-chloromethane, trifluoroborane etherate and ethane-1,2-dithiol in methanol, or iron(III) chloride will also cleave trityl ethers. Scheme 4.202 illustrates the use of zinc bromide in dichloromethane to remove a trityl ether in the presence of two allylic TBS ethers during a synthesis of ACRL toxin Illb. ... 

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